Lorena (Sis) Noble Southwood, 78, Lost Creek departed this earthly life on Sunday, November 15, 2020 in Hazard, Kentucky. She was the daughter of the late Bert and Ranie Noble. She was also preceded in death by brothers, Leon Noble and JB Jr. Noble; sister, Frankie Jean Noble; father and mother-in-law, Kelly and Cora Southwood. Lorena was a successful, respected and accomplished business woman. She was co-owner of Southwood Truck Parts, L and L Trucking, LS Trucking and Southwood Trailer Park. She also worked at Zenith in Chicago, Illinois. She is survived by her husband of 60 years, Lee Southwood; one son, Rodney Lee (Sandy) Southwood; one brother, Ernest (Von) Noble; three grandchildren, Cierra Southwood, Kellyn Southwood, Travis Lee Watts; six great grandchildren; as well as a host of nephews, nieces, cousins, friends and other relatives. Visitation, Tuesday, November 17, 6:00 PM. Funeral Wednesday, November 18, 1:00 PM with Bobby Collins officiating. Burial in the Southwood Noble Cemetery at Lost Creek. COVID-19 mandates will be observed.